Biological dressing based on placenta, by INTO/Disclosure
Regulation
Although the use of the amniotic membrane in the treatment of some types of wounds is already carried out in countries such as the United States, Germany and France, the project is still in the process of being regulated in Brazil. “It is not yet regulated as a treatment in Brazil. It is still experimental and is in the process of being regulated,” said the researcher.
The doctor believes that Into’s research can contribute to speeding up this process. “Although we have international references, we want to evaluate the applicability of this in our population, in this case, in the specific profile of Brazilians with wounds that are difficult to heal. We believe that this will contribute a lot to streamline the regulatory process”.
Sandra Baião warned, however, that it is not any wound that can receive a placenta-based dressing. These are specific wounds, which have some characteristics that make healing difficult. In these cases, the use of the amniotic membrane can help to accelerate this process and, with that, reduce, many times, the patient’s hospitalization time, the rehabilitation time, so that he can return to his activities that he had before suffering the injury.
funding
To capture the placentas, the Banco Multitecidos do Into team goes to the maternity ward, introduces itself to the mothers and explains what the study consists of, in order to obtain authorization to perform the procedure.
Sandra Baião said that the collection does not interfere at all in the progress of the delivery. “We wait for the baby to be born. When the placenta is removed by the obstetrician, instead of being discarded, it is collected in a sterile way and taken to Into”.
In the institute’s Multitissue Bank, the placenta is prepared to transform the part of the amniotic membrane into biological dressings. At the end of five days, the tissue receives a rectangular shape and is stored in packages that go to refrigeration, allowing the conservation of the dressing.
The doctor responsible for the research clarified that the amniotic membrane removed from the placenta is transparent, different from the skin of tilapia fish, for example, which is used in burns. “The amniotic membrane, once removed from the rest of the placenta, is completely transparent. It has a different aspect and also different properties from tilapia skin, in terms of healing”.
Study
In parallel to the Into research, there is a schedule for a larger multicentric study, which will involve other tissue banks, in this case, skin banks, but which depends on the regulation to be started. This study will involve, in addition to the Banco de Multitecidos do Into, the leather benches of Santa Casa de Porto Alegre; the Hospital Universitário Evangélico, in Curitiba; and Hospital das Clínicas, at the University of São Paulo (USP), which also work with amniotic membranes.
The objective is to use the membrane in areas where skin is removed for grafting, such as the thighs, and in patients who have suffered burns.
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