People infected with the coronavirus have an 88% lower risk of being hospitalized or dying from Covid-19 if they get sick again in the next ten months, compared with those who were not previously infected, according to a study published this Thursday ( 2/16) in the scientific journal The Lancet.

Research by scientists at the University of Washington School of Medicine in the United States is considered the most comprehensive to provide evidence on the protection generated by natural immunity by different variants of the coronavirus and how it decays over time.

The survey was based on the review and meta-analysis of 65 studies, carried out in 19 countries, which compared the reduction in the risk of Covid-19 among unvaccinated people who were infected by Sars-CoV-2 to unvaccinated individuals, without infection. previous year, until September 2022.

Protection against re-infection by one of the coronavirus variants in the pre-Omicron period was approximately 85% at one month and dropped to 79% at ten months.

However, the identification of Omicron and its variants changed this scenario significantly, increasing the recurrence of reinfections worldwide.

According to the North American review, people who had been infected by one of the previous strains (Alpha, Delta, etc.) and had contact with the first subvariant of Omicron (BA.1), showed strong protection against new infections in the first month (79 %), but it fell quickly, reaching only 36% in about ten months – a much lower percentage than previously observed.

Six of the analyzed studies showed significantly reduced protection against the BA.2 and BA.4/BA.5 sublines when the previous infection was with one of the first strains. The level of defenses was higher when the patient had already been contaminated by Omicron.

Patients who were previously infected with the original strain of the virus or the Alpha, Delta and BA.1 variants had a defense against reinfection, symptomatic illness and severe illness similar to that obtained after two doses of mRNA vaccines, such as those from Pfizer / BioNTech and from Moderna.

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focus on vaccination

Although the infection plays an important role in the body’s natural protection against new contacts with the virus, researchers point out that vaccination is still the safest way to acquire immunity.

“Vaccines remain important for everyone, protecting high-risk populations such as those over 60 years of age and those with comorbidities. This also includes populations that have not been previously infected,” says co-author of the article, Caroline Stein.

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